© Immuxøl

©Immuxøl: the first time – and only time!

Prologue:

LP discovered a unique common feature in the DNA of humans and hops: no plant on earth produces its own antibodies in the form of polyphenols as complex as hops. Moreover, hops DNA coincides with human DNA in such a way that their polyphenols, for both plants and us humans, release immune defenses at a concentration level that does not occur with any other plants in our diet. ©Immuxøl combines these strengths, which develop with even greater strength with the help of vitamin C + B2 and zinc.

Read more about the cause-and-effect link between ©Immuxøl and Covid-19

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Conclusion: ©Immuxøl strengthens our immune system in a manner both sustained and complex. Its special ingredient is the hop polyphenols, which reach their full potential for the first time in specific combined effect with vitamins and minerals. The legacy of the research behind this innovation will open up entirely new dimensions with effects convincing in itself. 

 

Thanks to its specific combinatorial requirements, the ©Immuxøl secret formula will prevent cheap imitations from being produced. Furthermore, the scientific plausibility of this product is presumed. However, LP consistently refrains from describing the general context out of its public digressions – in the interest of safeguarding expert knowledge, but also due to the fact that this discretion should not, may not, and cannot be used for research purposes.

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What are polyphenols and what are they typically good for?

It is commonly known

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that polyphenols are very important to nutrition and - among other things possess antioxidative, anticarcinogenic, anti-inflammatory, anti-microbial, antithrombotic, antiallergic, regenerative, immunoregulatory, blood sugar regulating, and blood sugar controlling properties;

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that polyphenols are able to prevent the onset of various types of cancer and are now even used as a sort of  cancer brake in chemoprevention measures, capable of supporting the organism, slowing down -and even stopping- the development of cancer at every stage (initiation → promotion → progression);

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that as anti-promoters, polyphenols protect our DNA from attacks from reactive oxygen free radicals by inducing certain enzymes, which in turn protect us from cell degeneration, promote normal cell division and maturation, and inhibit the growth of cancer cells that have already broken out;

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that as flavonoids or radical scavengers, polyphenols are capable of scavenging reactive oxygen species that would otherwise (under certain conditions) lead to oxidative stress in the organism, resulting in cardiovascular diseases and cancer as well as diabetes, age-related eye diseases, etc.;

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that polyphenols, through their antioxidants, prevent the oxidation of LDL cholesterol ingested from food, thus inhibiting the formation of calcium deposits on the inner walls of blood vessels (arteriosclerosis); consequently, epidemiological studies have shown that high flavanol intake greatly reduces the incidence of fatal heart attacks – and counteracts the causes of obesity if flavanol is taken in a purposeful way.

Furthermore, it is commonly known that hops (apart from their polyphenols) contain a wide range of components that promote health. The Mayas, Aztecs, Incas, Babylonians, Egyptians, and the Chinese knew this... as many as 3000 or more years ago (hops were chosen as the medicinal plant of the year as recently as 2007); namely, they knew that its extract has a multiple preservative, antibacterial, and antioxidant effect, and its sedative and anti-inflammatory ingredients have now been examined for the humulone effect (hydroxyphloroglucin with 3 isoprenoid side-chains), which provides regenerative healing to the liver. Furthermore, the effect in the humulone (C21H30O5) was proven to be “transcription-suppressing” for the exact gene that in turn belongs to the sanative enzyme cyclooxigenase-2 (COX-2). And – last but not least – it is also commonly known that the formation of prostaglandins* is inhibited above all. (*Term for tissue hormones responsible for pain, blood coagulation, and inflammation, such as acne, cirrhosis of the liver, dental caries, etc.)

NOTES: 

- Vit. C + B2 + Zn (inter alia) are added as catalytically supportive transmitters of polyphols for the purpose of their improved bioavailability.  

- Description above is intended as general information without promises of health benefits in the sense of "Regulation on Food Supplements". 

Introduction:

First of all, the following typically holds true: all plants contain polyphenols. These form the immune system of the plant itself. The constitution and conditioning of the latter will affect the consistency and the concentration of the polyphenol content. In most plants, however, these levels are very low or barely perceptible, and if perceptible, mostly found in the seeds of the fruit it bears. By ingesting these fruits, a person takes in 1g of polyphenols daily, assuming that they keep a “healthy” diet (which almost no one can claim these days). Our immune system has a huge leak in it without polyphenols, however. The industrialized nutritional science of today has missed out on this. It desperately needs to catch up!

So far, so good. But in reality, only meager amounts of polyphenols make it into the bloodstream, as they are water-insoluble and thus most of them are excreted again, unused. Only when combined with vitamin C, etc. – as a catalytic transmitter – is their bioavailability in our organism increased. When we ingest plants, the latter pass their antibodies, meaning their polyphenols, along with vitamins, proteins, minerals... on to our immune system. The trick is in the creation! It then happens that polyphenols without the latter have little effect, as do the latter without polyphenols. In this context, it is emphasized that among the countless types of plant in this world, there is one plant alone that contains the variety and concentration of polyphenols as prevalent as they are in hops or in their female umbel. In fact, no plant contains the type of polyphenols that share an affinity with humans such that hops do. This means that the plants’ own immune defenses act in almost the same way as those of humans. Conclusion: whatever is conducive to the immune response of the plant, consequently, helps us as well, mostly through our ingestion of its fruits (which are, simply put, the carriers of the polyphenols). This is the only way in which our immune-dependent diet works. Hops are the king of all plants in this regard!

 

In the course of his two years of research, LP managed to quantify all of the individual polyphenols camouflaged in the hops, examine them, and combine them with vitamins and minerals for the purpose of maximizing their development inside our organism. The results are two-fold: 1) hops + humans coincide especially well, which affects the affinity of the polyphenols. 2) With 1 ©Immuxøl tablet, a human absorbs the strength of more “bioavailable” polyphenols” than if they were to drink 10,000 liters of beer with hops, thanks to the effect of the combination described above.  This means that with just 1 ©Immuxøl-tablet, on average, more polyphenols make it into the human body than would via hops beer over a span of more than 50 years, assuming a “normal” level of beer consumption. 

 

With respect to creating higher bioavailability of hops polyphenols in the bloodstream, their combinatorial effect through vitamin C (VC) as a catalytic transmitter is mentioned first and foremost. This combined effect then supplements with meaningful complementarity and other vitamin + mineral combinations that can each be promoted as a health benefit in the sense of longer-lasting strength and more permanent stabilization of the human immune system. But for now, a bit more about the function of VC in  ©Immuxøl: Before it is finally pressed into a pill, another 5% of VC (among other things) is added to it – though not (or at least, not primarily) so that the immunizing effect of ©Immuxøl can be advertised better, but because VC in fact acts as a catalyst here, meaning it functions as the carrier substance for the polyphenols. 

                                   

Specifically, VC has the rare additional capability of being able to pass through the cerebral cortex without obstruction. At the same time, however, it also carries important neurotransmitters “piggyback” style, so that – especially in the case of ©Immuxøl – essential hops polyphenols, along with their antioxidative, regenerative and antithrombotic effects can unfold where they would never have made it otherwise without VC to “smuggle” them in:the brain: prophylactic cerebral sclerosis resistance (brain calcification prevention) or Apoplexia cerebri Prophylaxis (stroke danger prevention). Furthermore, this special ability of VC to act as a catalyst or “polyphenol transmitter” also includes overall significantly higher bioavailability of hops polyphenols in the blood stream. Naturally, we do not advertise this expressis verbis. However, in order to avoid withholding such important information from the customer, there is the general information sheet mentioned above that contains notes on all the most important effects of polyphenols, along with the note on the catalytic transmitter ability of VC (in complementarity with VB2 + Zn) on the ©Immuxøl packaging itself.

Im Labor

This is what the optional promotional buzzword prophylactic hop polyphenols refers to, without which the product name ©Immuxøl* would already be self-explanatory (*because an unambiguous and therefore non-deceptive invented name =innocuous brand name), therefore these are not considered promises of health benefits within the meaning of the Regulation on Food Supplements (NemV) insofar as the German Ministry of Health has issued the all-clear as follows based on the term definition below. Because the term prophylactic is understood to mean “prevention of sickness” (or just prevention), and in such a way that according to the German Ministry for Health (BMG), prevention is a generic term clarified in the health care industry that refers to the strengthening of [a] motivation (psychological) and [b] health literacy1 of people, with the goal of “reducing behavior that is harmful to health and promoting behavior that is beneficial to health...” (1a term, according to the BMG, for “the ability to find, understand, evaluate and apply health information in order to be able to make appropriate everyday decisions regarding health” – which we explicitly do by making helpful general information available about polyphenols). 

 

Explanations on the most important health-promoting factors, such as specific tips on how to make your own life more health-conscious and how you can change your lifestyle to be advantageous to your health, can be found in the BMG’s official “Guide to Prevention and Promotion of Health,” namely in the form of the Prevention Act passed in 2016. This legally required guide observes on page 42, III. Diet, 1. A healthy diet promotes health, as follows:

 

... eating is not only essential to live. In addition to its high cultural and social significance, diet is also an important factor for one’s well-being and life satisfaction... The essential function of diet is to provide energy and body components that are essential to live. It has an enormous impact on metabolism and the immune system. Our eating habits have significant influence over our health as well as the prevention and progression of sicknesses. Therefore, by maintaining a sensible diet, you effectively contribute to the prevention of high blood pressure, vascular calcification, heart attack, or diabetes mellitus type 2, for example. Choosing the right foods and taking a sensible approach to it will keep you healthy and make you feel better. Although nutritional awareness among Germans has improved, many still don’t know what healthy components are hiding in our food and which components provide us with the necessary energy...”

 

Accordingly, lawmakers simply ask that we agree to promote health to the best of our ability within the framework of the Prevention Act outlined by the Federal Ministry for Health, while ensuring that our contribution (keyword: ©Immuxøl) does not cause any damage to human health – in the worst-case scenario! – while, as a rule, promoting both mental health (“motivation” is the first prevention criterion mentioned according to the BMG) and physiological health (hops were chosen as the medicinal plant of the year in 2007) with a healthy diet (prophylactic). (Cf. the BMG quote above). However, it is immaterial whether the Prevention Act primarily targeted health insurance political influences or was reserved for the nutrition-conscious health care system at the same time. Either way, it fits with our principles! If we only name the ingredients, meaning the individual polyphenols along with the other active ingredients in ©Immuxøl (with the corresponding measurement), this is not in itself an advertisement, but merely an upfront statement of the ingredients. Moreover, if we add a description of polyphenols and the effects of which they are capable that are generally known, this is likewise innocuous. We are merely repeating a summary of this general knowledge, which lawmakers rightly ask us to do anyway (cf. BMG). 

 

Within the framework of this Prevention Act, however, it must also be noted here that the blatant combination of vitamin C and zinc as an immune-boosting nutritional supplement is used much too carelessly from a molecular medical standpoint, as up to now there has been no evidence whatsoever that the former does not also allow the latter into the brain and back out again by means of its transmitter function. Nevertheless, all health authorities support the intake of both unisono without hesitation; (further) evidence that everything officially allowed/supported in the sense of nutritional supplements is by no means any more beneficial to our health than many things not - or not yet - officially permitted in the sense of nutritional supplements are likewise not hazardous to our health or may even be essential to health. So far, so good. LP has likewise addressed both legal practicability and scientific accountability and came to the following (only partially reproduced here in order to safeguard expert knowledge) solution:

 

To add the hops polyphenols (HP) used as a basis here, along with 5% vitamin C (VC) plus 3% vitamin B2 (VB2) – better known as riboflavin, which, with the molecular formula C17H20N4O6 is not water-soluble in practice, but when combined with phosphate and spec. sodium oxide dissolves well in water and thus increases the bioavailability of VB2 in the blood by a considerable degree. Various federal, EU, EFSA registers already designate this compound designated by LP under the name “riboflavin phosphate sodium” (C17H20N4NaO9P) as beneficial to health; it is also already marketed occasionally, although the nomenclature for this compound obviously still lacks final standardization. We consequently refer to it as “RPS” for short. 

 

This RPS is nothing more than VB2 in “salt format” at first. It will tentatively be manufactured as follows: Riboflavin (C17H20N4O6) reacts with phosphoryl chloride (POCl3) and with sodium hydroxide (NaOH) + water (H2O) to become RPS (C17H20N4NaO9P) and hydrogen chloride (3HCl). LP will specifically manufacture RPS if necessary. In particular, this has an amphotheric secondary property - discovered by LP - that binds the mineral “zinc” as follows and thus carries it away: RPS breaks down during metabolization into riboflavin and sodium phosphate. In this way, VB2 makes its way into the brain without obstacles and can fully develop its “prophylactic” and convalescent effect once it has decoupled from the trisodium phosphate (C17H20N4NaO9P à C17H20N4O6 + Na3PO4). The sodium phosphate detached from VB2 bonds with the zinc that has made its way into the brain with the help of VC as a transmitter thanks to the “amphotheric secondary property” achieved by its previous substitution (made possible by free valances!), and smuggles the latter back out through the brain as follows without causing harm, in the form of zinc phosphate quantum satis: 

 

C17 H20 NNOP → C17 H20 NO6 + Na3 PO4 | Zn + Na3 PO4 → 3Na + ZPO4

 

In this way, the nutritional supplement known as ©Immuxøl features 5 unique characteristics at once:

  1. HP makes it into the brain with the help of VC, significantly increasing its bioavailability in the blood at the same time. 

  2. Adding VC as well as VB2 and zinc unquestionably increases immune defense.

  3. The bioavailability of VB2 is significantly increased in combination with Na and P, and as RPS.

  4. The amphotheric additional property of RPS allows zinc to be admitted harmlessly - even into the brain.

  5. The effectiveness of HP is thus developed with nearly optimal synergy in our organism.

One ©Immuxøl tablet contains 5 mg HP, 5 mg VC, 5 mg VB2, 5 mg Zinc, along with others, vital ingredients, declared trade secrets in LP’s description – a top combination with unparalleled immune defense strength.

Melius est prevenire quam preveniri. 

Hop polyphenols and their applications

Preamble:

The following very brief summary of hop polyphenols outlines the characteristics of our FEAT research work. The cooperation architecture postulates the IP-protected research context in which scientists can develop patentable achievements to the point of marketable applicability. As a research example, the topic of hop polyphenols is arbitrarily highlighted here, as an illustration of just one of our innovative technologies, which have enabled us to successfully get to the heart of the cause, previously so complex and intertwined, of our human illness, aging and death.  Particularly in the field of research into preventive medicine, LP has been able to use new methods to identify many (still largely ignored by conventional medicine) therapeutic substances, some of which have a great number of different effects, yet at the same time form a complementary unified principle. By means of this new research discipline, LP is able to ward off diseases causally, i.e. to avert them prophylactically, instead of having to fight them symptomatically after they have already broken out. This preventive medical key-lock-principle is based primarily on maintaining a stable immune system which, as is well known, is weakened in conventional medicine (e.g. chemotherapy, antibiotics, cortisone, etc) at the very time when it is most severely challenged. Within this range of research, LP has decoded not only polyphenols but also pectins in sugar beet, the efficiency of which, among other things, only comes into effect through LP protein analysis. 

However, before we start with the explanation about the functionalities of hop polyphenols, let's take a short trip to the remote Hunza Valley to see the eponymous minerals, the causative principle of those minerals - de facto “life-prolonging” - is ideally suited to illustrate the immune-boosting mode of action of hop polyphenols in the human organism, whose similar but far more complex effectiveness is subsequently summarized.

Art. 1

First a short trip to the Hunza Valley:

The Hunza Valley is a sparsely populated plateau in the Karakorum Himalayas, the subject of dispute between Pakistan, India and China. Statistics show that the approximately 20,000 Hunzakuts who live there have an above-average life expectancy combined with below-average figures for diseases. This is due to (A) the unique consistency of the naturally pure O2-rich spring water there (the source of the Indus River) and (B) the minerals contained in this water (Hunza minerals). These float undissolved in the water due to a combination of their high specific surface area and their small and fine particle size distribution. Their bent ends carry a high specific charge. Their outline is polygonal. Ingestion of these minerals (together with the O2-rich water) leads to immediate binding of toxic metabolic waste products in the large intestine, which dramatically strengthens the human immune system. As there is a prevailing maximum concentration of coliform bacteria permanently in the large intestine, this organ therefore represents the greatest continuous stress on the immune system.

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This is where the Hunza minerals come into play: Because of the many free valences at their bent ends, they can take over massive amounts of coliform bacteria in the large intestine, and excrete them harmlessly. These putrefactive bacteria or cell tissue destroyers are, as we know, the most effective of agents for decomposition. Consequently, the large intestine contains the strongest part of our immune system. With the help of the Hunza minerals, however, the enemies of life (i.e. coliform bacteria) produced there continuously can be immunized in such a way that they are neutralized as soon as they are formed, and can then be quickly and regularly removed. If Hunza minerals are added to our digestive tract in the same consistency as that of the natural oxygen-rich water, therefore, our large intestines will have significantly fewer putrefactive bacteria. As a result, the strongest part of our immune system, which is located there, is eased to such an extent that its newly-released resources are sent via the autonomic nervous system (controlled by the hypothalamus) to weak points where cancerous diseases - mainly virus-induced - are urgently waiting for immunizing support. 

 

The cancer cell tissue itself always starts to proliferate only when information about the cell-structure instability that has laid dormant in every human being since birth is wrenched out of its natural dormancy by the infiltration of waking information (usually by a virus). Viruses are known to be the most efficient carriers of information, predictable by algorithm and therefore able to be decoded.  (This is why viruses are also successful in disrupting the Internet, as relatively algorithmic programs). In humans, however, viruses always initially attack life-related bacteria, which unfortunately offer themselves up as far too perfect virus hosts. Restoration of the original natural cancer cell dormancy can therefore only be achieved by removing the causative waking information from the cancer cell tissue thus awakened and interpreting its cell structure instability (via new antivirus-induced information) as “Everything’s fine!”. But after every awakening of the cells it becomes increasingly difficult to restore this original state. A comparison could be made with an archaic ethnic group being given some enlightening thoughts of emancipation far too soon, when their “Wild-behavior DNA” was not yet ready for such a progressive process of socialization (with the consequence being that these simple people attached to their “stupid thoughts”, having led a hitherto peaceful coexistence, would end up being let loose destructively on more advanced civilizations). 

  

Based on this short trip to the remote Hunza Valley to see the eponymous minerals, the causative principle of those minerals, found in hops - de facto “life-prolonging” - is down to the polyphenols, whose similar but far more complex effectiveness is summarized here. The molecular-medical investigation of these polyphenols is carried out by means of microbiochemical processing, semi-biophysical protein analysis and microbial enzymatic high-tech processing sequences, all of which are the research legacy of LP. 

Art. 2

Specifics: 

In the process of development of Halal beers by LP (for His Royal Highness Sheikh Muhammed Bin Rashid Al Maktoum), the nutritionally important beer ingredients “hop polyphenols”, which had previously been discarded, were for the first time comprehensively deciphered, i.e. fragmented and quantified in terms of molecular structure, subjected to genome sequencing,  microbial and enzymatic examination, deproteinized and isolated microbiochemically and finally prepared for application. During this research process, LP discovered numerous health benefits in them, so that it is all the more surprising that their compact, natural healing tincture has received so little attention to date.

 

[In beers, however, the core of the turbidity-related polyphenols is the group of flavan-3-ols with respect to changes in the polyphenol spectrum, in order to optimize colloidal stability, on one hand, and to improve analysis of the reduction of this group of substances in beer aging, on the other hand. Besides the phenolic aspect, special attention is paid to the proteins involved in turbidity formation. Both the polyphenol results and the protein analysis results are then implemented into the turbidity-related process. As a result, the methodology developed is examined for correctness, whilst additional influential factors such as oxygen and various metal ions are observed more closely. The best known representatives of the flavan-3-ols in beer are the monomers catechin and epicatechin and the dimers procyanidin B3 (catechin(4α→8)catechin), prodelphinidin B3 (gallocatechin(4α→8)catechin). Quantitatively, polyphenols have hardly any relevance in beer production. In qualitative terms, however, they have an ever-increasing influence on the process parameters and properties of the finished beer. The polyphenols in beer are derived from malt and hops, i.e. 80% of the proanthocyadins in beer are derived from malt, the remainder from hops (0.15 to 0.22% of dry weight of barley consists of proanthocyanidins). It is this “remainder”, in the hops, that we are interested in here!]

The large number of hop polyphenols and phenols exhibiting different effects requires individual dosage, especially since the benchmark criteria for the selection of individual polyphenols in their respective dosage depending on age, sex, skin type, skin pH value, metabolism, mental state, diseases as well as many other states of well-being, such as in the context of TCM and other healing methods, also have a decisive influence. A more concrete approach for cosmeticians, alternative practitioners, dermatologists and physicians arises from the examination of the polyphenols which are quantified protein analytically and isolated individually, which in preventive medical consistency leads to the distinction from the conventional medicine mentioned above. In addition to various DNA sequencing technologies, LP uses spectrophotometric methods, namely HPLC*analysis (≝*high-performance liquid chromatography), for precise determination of each individual phenol to ensure the individual and complete detection of each phenolic acid together with all other hop constituents. For the examination, quantification and isolation of every single phenolic substance LP developed a new – proprietary – method of protein analysis, which is the actual key to the know-how of local innovation: 

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Art. 3

Deproteinization:

By means of protein analysis, the hop polyphenols are “purified” of amino acids: for example, 0.1 mol/l HCL and 500 µmol/l norleucine are added by microultrafiltration or centrifugation (1 h at 2000 rpm). The free amino acids are determined in 3 different ways (see simplified figure):  

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  1. Using the IC-analytical-biochemical method (IC=ion exchange chromatography) for maximum precision separation of the individual elements according to their respective charge; for this purpose, initially charged functional groups are formed on a polymer matrix, which have previously bonded counter ions –reversibly – (to put it simply: cations in cation exchange and anions in anion exchange). 
     

  2. By post-column derivatization with ninhydrin (C9H6O4), where the amino acid analysis here a) serves to quantify the proteins and peptides, b) to determine their individual identity on the basis of the amino acid composition, c) for the most precise protein and peptide structure verification possible, c) for optimum evaluation of the individual fragmentation strategies, d) for better traceability of the peptide pattern characterization, and e) for detectability of any atypical amino acids present in proteins and peptides. However, prior to this amino acid analysis, a protein or peptide has to be hydrolyzed into the individual amino acids. As a rule, the amino acid components are then derivatized for analysis. 
     

  3. By UV/VIS analysis, i.e. by electron absorption spectroscopy, which presupposes, for example, that an electron is raised from an occupied, lower orbital to an unoccupied, higher one, which, however, can only take place if the energy of the absorbed photon corresponds exactly to the energy difference between these two energy levels.  In the meantime, the wavelength of the light absorbed in this way can be calculated exactly for this energy required [E=h∙f=(h∙c)/λ)], where E = energy, h = Planck's quantum of action, c = speed of light, f = frequency and λ= the wavelength of the electromagnetic waves. 

In short, the hydrochloric acid hydrolysis method is used: 6 mol/l HCL and 400 µmol/l Norleucine. For this purpose hydrolysis jars are flushed with nitrogen and hermetically sealed. The contents are hydrolyzed at 110°C for 22 hours. After cooling, the hydrolysate is evaporated under vacuum, dissolved in 500 µl of initial buffer solution of amino acid analyzer, membrane filtered and 40 µl is used for the analysis. The above amino acid analysis is performed accordingly: the unfiltered samples are centrifuged at 9000 rpm and 4°C for 30 minutes. The beer proteins are then precipitated with trichloroacetic acid (20 % w/v) at zero °C for 1 hour. The same proteins are then centrifuged at 13,000 rpm and zero °C for 1 hour. The pellet is then washed twice with 25 ml –20°C cold acetone and then centrifuged at 15°C at 13,000 rpm for ¼ hour. The lyophilized proteins thus obtained are then transferred to the buffer solution and centrifuged at 40,000 rpm for 1 hour. The buffer solution itself consists of 8 M Urea, 15 mM DTT, 10% glycerol and small traces of bromophenol blue.

Art. 4

Dosage:

With their daily food, humans ingest an average of 1 g of polyphenols in a wide variety of ways: in various fruits, vegetables, coffee, cocoa, tea, wine, etc. and – a route which has so far largely been ignored – dermally! Although surprisingly much is known about the diversity of beneficial potential in hop polyphenols, research medicine in general still knows very little about their oral and dermal application possibilities. Nevertheless, hop polyphenols are far more effective than most of the above-mentioned polyphenols. It should also be emphasized that everything that works quite well in the research labor in the test tube may be completely different in the human organism. LP has set himself the goal of getting to the bottom of this range of active ingredients, and the effect of quercetin2 was particularly positive. LP used various research studies for this purpose, which were carried out on the following mammals: Rattus = 61 mg·kg−1oral (LD50) | Muroidea = 159 mg·kg−1oral (LD50).

LP initially used quercetin, an active ingredient extracted from hop polyphenols and perhaps the most important of all, for his application research. As a result, this is specifically discussed. However, first of all the following note: quercetin is proven to have anticarcinogenic efficacy, which is mainly due to its antioxidative potential. Quercetine also acts as a particularly efficient radical scavenger, similar to vitamins A, C and E. Furthermore, LP found an increased degree of activity of the oxidation inhibitors. On the other hand, its much-discussed mutagenic properties could be refuted as completely non-toxic, especially as no carcinogenic side effects were detectable even after

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numerous tests on animals. Quercetin is effective against cancer (including skin cancer) so that rupturing or ruptured tumor cells are literally

hindered in their growth and even die off as a result. –|– Finally, it should be mentioned that quercetin (similar to allopurinol) inhibits xanthine oxidase and thus prevents hyperuricemia and the resulting gout by lowering uric acid levels, but despite its positively classified specifics, it should herewith be stressed that excessive quercetin dosage is not advisable after in vitro toxicity models by LP have concluded that its increased and prolonged uptake may have toxic effects. 

… And because quercetin (with the molecular formula C15H10O7) is hardly soluble in water (<1 g·l−1at 21°C), LP uses acetic acid under specific semi-biophysical conditions (i.e. catalytically), which is then removed from the (lecithin-based) emulsified hop polyphenol extract. LP uses his own new amino acid sequencing methodology, with integral and differential computational modules that are applied for the first time here, by additional virus genome-vector-logical fragmentation and DNA-synthesis. 

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The information required for enzyme synthesis is stored in the genetic material in an algorithmically encoded form in the same way as in other proteins. Their DNA molecules are made up of four different bases, the chronological sequence of which also determined the procedural sequence of the individual amino acids during the synthesis of proteins, enabling the individual DNA pieces to be read individually. By means of restriction endonucleases (REN) combined with physical shear force processes, the entire genome of the donor-organism is first multiplied

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and then (using special enzymes prepared by LP & Co.) broken down into manageable fragments. These result in a multitude of different DNA sequences, most of which, however, are waste (usually 1 to 5000). 

 

This gene-vectorial high-tech fragmentation process always takes place first in the smallest organisms on earth, without which no life form, no life would be possible: the bacteria! They, of all organisms, are always threatened by viruses because the latter are too keen to inject their DNA or RNA into bacterial cells, which leads to the reprogramming of the bacterial protein synthesis apparatus in such a way that new viruses are produced instead of bacterial proteins… 

​In order to be able to break down this overall development process into all its sub-steps and causally prove it, LP uses specially prepared restriction enzymes to cut up the foreign DNA caused by the virus axially in order to draw algorithmic conclusions about its stem cell development and thus serve as mathematical instruments for enzyme synthesis. Then, via reverse transcription, a cDNA can be produced and subsequently converted into a double-stranded DNA, thus completing the circle of this gene-vectorial synthesis. 

Art. 5

Hop synthesis:

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1 Comparable with the antiviral acylphloroglucinol derivatives which could be isolated from the species *Kanuka ericoides and *Kanuka sinclairii since 1992 (*Austro-Asian place name). The following two chemotypes are postulated for the essential oils of the first type: the widespread p-cymene-poor type (<5 %) and the ratherscarce p-cymene-rich type (5-30 %). However, both types contain α-pinene as the main component with a content of 40-80 %.

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For example, the extract simply pressed out in this way has a multiple preservative, antibacterial and antioxidant effect. Its sedative and anti-inflammatory elements are already of such essential relevance that the effect of the humulone alone (hydroxyphloroglucin with 3 isoprenoid side chains) provides alcohol consumers with regenerative healing of their permanently stressed liver. LP found this anti-inflammatory effect as “transcription-suppressing” in humulone (C21H30O5) in exactly the gene that belongs to the curative enzyme cyclooxygenase-2 (COX-2). On this basis the formation of prostaglandins* can be inhibited. (*Tissue hormones responsible for pain, blood coagulation, inflammation such as acne, cirrhosis of the liver, dental caries, etc.).

 

Art. 6

Cost Factor and Research Outlook 

The polyphenol content varies depending on the hop vintage, growing region and the hop variety itself. Although little attention has been given to research into hop polyphenols for far too long, it does now seem that a greater sphere of interest is emerging in this field after all. As a result, the cost evaluation for industrial extraction of polyphenols can hardly be based on fixed empirical values. Only cost data for different hop extraction processes can be based primarily on the substance, which in tantum means that the actual hop processing (already practiced) does not give rise to any additional costs from its value-added chain, as this is already part of the general beer production process. Admittedly, parallel to this, approximate values can be formulated, which are documented in quite different ways by the food and pharmaceutical industries, but based on such process technologies, practical projections could be incorporated into the local cost evaluation. 

      

Overall, the polyphenols serve as high-quality by-products of large-scale hop processing for the brewing industry, the actual purpose of which has so far only been to concentrate the bitter substances. As a result, inexpensive raw materials are available for the local production process at times, which makes a positive contribution to economic viability. In practice, this would look as follows: 30,0 kg hops yield 1,0 kg polyphenols. Altogether, apart from their polyphenol content, hops contain a wide range of health-promoting components. 

 

2 Quercetin is approved as a foodstuff in Europe and America, classified as a food supplement, i.e. not a medicine! Alcoholic combination effect tautologically excludes local procedure. According to official approval, there is no upper-level risk, but LP confidently advises against overdosing. Furthermore LP’s use of hop polyphenols correlates legally with the OLG Frankfurt a.M. Ruling of 04.12.2014, Ref.. 6 U 112/14: According to this, a new foodstuff in the sense of the NFV is only considered to be a new foodstuff if the primary molecular structure of the foodstuff or of the ingredient is changed in such a way that, by changing the molecular structure, the biochemical properties of the original substance have also been modified and it would therefore seem that this could potentially have effects on health. As this excludes LP’s extraction and application of hop polyphenols (deproteinization does not cause changes in biochemical properties in the original substance), the NFV states that the existence of new food products is not affected.

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